"Innovation is found where people, ideas
and technologies intersect."

Patrick Verheyen, Head J&J London Innovation Center

"We need to join forces if we want to solve
Alzheimer's Disease."

Bart De Strooper, Professor at VIB and KU Leuven, Co-director LIND

Parkinson's disease

Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder that leads to problems with movement control and other non-movement-related symptoms. PD occurs when neurons in the substantia nigra die or become impaired causing a loss of dopamine, which results in abnormal nerve firing patterns in the brain, leading to impaired movement. Studies have shown that patients lose 60 to 80 percent of their dopamine-producing cells before symptoms appear. Recent studies also have shown that people with PD lose nerve endings that produce norepinephrine, which may be linked to non-motor features in PD, such as fatigue and blood pressure abnormalities.

The average age of onset is 60 and the risk increases significantly with age. It strikes 50 percent more men than women.(1) Although some cases of PD appear to be hereditary or can be traced to a specific genetic mutation, most do not appear to run in families. One theory is that PD results from a combination of genetic susceptibility and exposure to one or more environmental factors, such as pesticides, which trigger the disease.